People who quit taking anti-obesity meds, including popular GLP-1 receptor agonists, may regain a significant amount of weight after eight weeks, a new study finds.
People taking weight-loss drugs… including popular GLP-1s … may regain a significant amount of weight within months of stopping their medication.
In a new study, researchers reviewed 11 clinical trials investigating weight rebound after discontinuation of an anti-obesity med.
Overall, they found the pounds started creeping back on after 4 weeks and reached significant levels by 8 weeks.
The studies included about 1,600 patients who stopped treatment and 900 in control groups… and focused on 5 types of anti-obesity meds.
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GLP-1 Receptor Agonists
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GLP-1 and GLP dual Ras
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Orlistat
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Phentermine-Topiramate
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Naltexone-Bupriopion
The analysis found significant increases in weight after 8, 12 and 20 weeks of discontinuation, followed by a plateauing.But by the 12-week mark, major increases were only observed in patients using GLP-1 drugs, according to the researchers.
The authors say, “While the amount of weight regain varies depending on the specific drug, there is a broad trend in associated weight regain after the course of medication concluded.”
Source: BMC Medicine
Author Affiliations: Peking University People’s Hospital
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